The estimation of the potential impact of general lighting in human health and wellbeing is a challenging field of science. A great progress has been done in the last 20 years with the discovery of the ipRGC (intrinsically photosensitive retinal ganglion cells), and the proposal of different functions of merit for their action spectra (such as the WELL Building Standard and the CIE S026:2018). Beyond this, we already proposed a model for the estimation of the melanopic potential of lighting setups, that we refined at LHWC 2018. We go one step further in our approach taking into consideration the energy impact of the melanopic stimulus and how new approaches have to be considered to balance, during a whole temporal window (day, week, year), energy consumption against proper melanopic stimulus. It is not anymore about the “lumen/watt”. It is about proper lighting for human health and wellbeing, without the constraint of current energy metrics.