The COVID-19 pandemic caused by SARS-CoV-2 has raised awareness regarding the significant potential of UV-C LEDs. There is strong interest in new technology that can inactivate bacterial and viral pathogens, over and above chemical treatments and/or reliance on Hg-containing tube lamps, and recent technical breakthroughs in UV-C-transparent epitaxial structures provide important roadmap opportunities. In the near future, these developments and the associated pent-up demand will usher in an unprecedented era of UV-C LED and application development, open an untapped and underestimated billion-dollar market for LEDs; and make our world cleaner and safer. This talk will provide an up-to-date snapshot of III-Nitride UV-C LED technology and applications, and project an entitled performance and cost roadmap for the future.